Description

Domperidone (Domperidone Maleate): A Gastrointestinal Prokinetic Agent

Important Note: Domperidone is a prescription medication and should only be used under the guidance of a healthcare professional. This description is for informational purposes only and does not constitute medical advice. Always consult your doctor or pharmacist before starting or stopping any medication, including Domperidone.

Product Overview:

Domperidone (Domperidone Maleate) is a prokinetic agent primarily used to relieve symptoms associated with gastrointestinal motility disorders. It works by increasing the movement of food through the digestive tract, thereby improving digestive function. Unlike some other prokinetic agents, Domperidone has a relatively minimal effect on the central nervous system, leading to a lower incidence of side effects.

Key Indications:

• Gastroesophageal Reflux Disease (GERD) Symptoms: Domperidone can help alleviate symptoms of GERD, such as heartburn and acid reflux, by accelerating gastric emptying.
• Nausea and Vomiting: It is often prescribed to manage nausea and vomiting, particularly in cases associated with gastroparesis (delayed stomach emptying) or other motility disorders.
• Functional Dyspepsia: Domperidone may be used to improve symptoms of functional dyspepsia, including upper abdominal pain, bloating, and fullness.
• Post-Operative Nausea and Vomiting: It can be used to prevent or treat nausea and vomiting after surgery.

Mechanism of Action:

Domperidone is a dopamine D2 receptor antagonist. By blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) in the brain and the gastrointestinal tract, it reduces nausea and vomiting and promotes gastric emptying and intestinal motility. Its peripheral action minimizes the potential for central nervous system side effects associated with other dopamine antagonists.

Dosage and Administration:

Dosage of Domperidone varies depending on the individual's condition, age, and other factors. It is crucial to follow the prescription instructions provided by your doctor precisely. Common dosage forms include tablets and oral suspensions. Dosage is typically adjusted based on symptom response and should be reviewed regularly by your physician.

Potential Side Effects:

While generally well-tolerated, Domperidone can cause side effects in some individuals. These can include, but are not limited to:

• Gastrointestinal: Diarrhea, constipation, abdominal pain
• Neurological: Headache, dizziness, drowsiness
• Endocrine: Galactorrhea (breast milk production), amenorrhea (absence of menstruation), gynecomastia (breast enlargement in males) – these are rare but serious side effects.
• Cardiac: In rare cases, prolonged QT interval has been reported. This is a serious cardiac side effect and necessitates close monitoring, especially in patients with pre-existing cardiac conditions or those taking other medications that can prolong the QT interval.

Contraindications:

Domperidone should not be used in individuals with:

• Known hypersensitivity to domperidone or any of its components.
• Prolactinoma (a type of pituitary tumor).
• Conditions that may prolong the QT interval.
• Patients concurrently taking medications that prolong the QT interval.

Drug Interactions:

Domperidone can interact with several other medications, including those affecting the heart rhythm. It's essential to inform your doctor about all medications, supplements, and herbal remedies you are currently taking.

Pregnancy and Breastfeeding:

The use of Domperidone during pregnancy and breastfeeding should be carefully considered and discussed with a healthcare professional.

Storage:

Store Domperidone as directed on the product label. Keep out of the reach of children.

Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult your physician or pharmacist before using Domperidone or any other medication. They can provide personalized guidance based on your specific health needs and medical history.