Description

Lansoprazole & Dexlansoprazole: Understanding the Differences and Uses

This product description outlines the key differences and similarities between Lansoprazole and Dexlansoprazole, both proton pump inhibitors (PPIs) used to reduce stomach acid production. While sharing a similar mechanism of action, they differ in their pharmacokinetic properties and are indicated for slightly different purposes.

Lansoprazole:

• Chemical Name: 2-[[(3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
• Mechanism of Action: Lansoprazole inhibits the H+/K+-ATPase enzyme system, the final step in gastric acid secretion, leading to a significant and long-lasting reduction in gastric acid production.
• Indications: Lansoprazole is indicated for the treatment of:
  • Gastroesophageal Reflux Disease (GERD) including erosive esophagitis healing and maintenance of healing.
  • Zollinger-Ellison syndrome.
  • H. pylori eradication in combination with antibiotics (as part of a triple or quadruple therapy regimen).
  • Short-term treatment of duodenal ulcers.
  • Short-term treatment of gastric ulcers.
  • Prevention of NSAID-induced ulcers.
• Dosage Forms: Available in various forms including capsules, delayed-release capsules, and oral granules.
• Pharmacokinetics: Lansoprazole is rapidly metabolized, with peak plasma concentrations reached within 1-2 hours of administration.

Dexlansoprazole:

• Chemical Name: (S)-2-[[(3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
• Mechanism of Action: Dexlansoprazole is the S-isomer of lansoprazole. It acts as a more potent inhibitor of the H+/K+-ATPase enzyme than lansoprazole itself.
• Indications: Dexlansoprazole is primarily indicated for the treatment of:
  • Gastroesophageal Reflux Disease (GERD), including erosive esophagitis healing and maintenance of healing.
  • Symptomatic GERD.
• Dosage Forms: Typically available as delayed-release capsules.
• Pharmacokinetics: Dexlansoprazole offers improved pharmacokinetics compared to racemic Lansoprazole, allowing for once-daily dosing with effective acid suppression and improved symptom relief for some patients.

Key Differences Summarized:

Important Note: This information is for educational purposes only and should not be considered medical advice. Always consult your physician or pharmacist before starting or changing any medication, including Lansoprazole and Dexlansoprazole. They will help determine the appropriate medication and dosage based on your individual health needs and medical history. PPIs can have potential side effects, and long-term use should be discussed with your healthcare provider.