Description

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Ion Pair Reagents: Elevate Your Chromatographic Separations

Struggling to achieve optimal separation and consistent peak shapes for challenging polar and ionic compounds in your chromatography? Our premium Ion Pair Reagents are specialized mobile phase additives meticulously designed to overcome these challenges, delivering superior resolution, enhanced retention, and unparalleled peak symmetry for your most demanding analytical applications.

What are Ion Pair Reagents?

Ion Pair Reagents are amphiphilic molecules (possessing both hydrophobic and charged characteristics) that are added to the mobile phase in reversed-phase liquid chromatography (RP-LC). They work by forming a neutral, hydrophobic "ion pair" complex with charged analytes. This complex can then interact more strongly with the non-polar stationary phase, effectively allowing for the retention and separation of highly polar or ionic compounds that would otherwise elute too quickly or exhibit poor peak characteristics.

Key Features & Advantages

• Exceptional Purity: Our Ion Pair Reagents are manufactured to the highest purity standards, ensuring minimal baseline noise, absence of interfering peaks, and consistent batch-to-batch performance. This translates to more reliable data and reduced method development time.
• Optimized Performance: Specifically formulated to enhance the separation of charged analytes, improving peak shape, symmetry, and resolution, especially for compounds like peptides, amino acids, nucleotides, organic acids, and basic drugs.
• Broad Spectrum of Chain Lengths & Counterions: Available with various alkyl chain lengths (e.g., C4, C6, C8, C12) and counterions (e.g., acetate, phosphate, trifluoroacetate, hydrogen sulfate) to provide flexible selectivity tuning and optimize your specific separation needs.
• MS-Compatible Options: We offer a selection of volatile Ion Pair Reagents (e.g., those with trifluoroacetate or formate counterions) specifically designed for direct compatibility with Mass Spectrometry (MS) detectors, minimizing signal suppression and maximizing sensitivity.
• Versatile Application: Ideal for use in HPLC, UHPLC, and preparative chromatography across a multitude of industries.
• Reproducible Results: Our stringent quality control processes guarantee consistent product quality, ensuring excellent reproducibility across different runs and between different laboratories.

Benefits for Your Laboratory

• Reliable Data: Achieve higher quality data with improved peak resolution and reduced interferences, leading to more confident identification and quantification.
• Expanded Analytical Capabilities: Successfully analyze highly polar and ionic compounds previously difficult or impossible to separate by traditional RP-LC.
• Method Development Efficiency: A wide range of reagents allows for quick method optimization and selectivity tuning, saving valuable time and resources.
• Reduced Troubleshooting: High purity and consistency minimize issues related to baseline drift, ghost peaks, and column contamination.
• Enhanced Detector Sensitivity: MS-compatible options ensure your valuable samples can be analyzed without compromising mass spectrometry performance.

Typical Applications

Ion Pair Reagents are indispensable for the chromatographic analysis of a diverse range of charged molecules, including:

• Pharmaceuticals: Separation of active pharmaceutical ingredients (APIs), counterions, related substances, and metabolites (e.g., basic drugs, acidic compounds, peptides).
• Biomolecules: Analysis of amino acids, peptides, nucleotides, oligonucleotides, and related biological compounds.
• Environmental Analysis: Determination of ionic pollutants, surfactants, and various organic acids and bases in water and soil samples.
• Food & Beverage: Analysis of vitamins, preservatives, and other ionic additives.
• Forensics: Separation of drugs of abuse, their metabolites, and other relevant compounds.
• Industrial Chemistry: Characterization of detergents, surfactants, and ionizable polymers.

Available Formulations

Our Ion Pair Reagents come in various formats to suit your workflow:

• Alkyl Sulfonates (Anionic Reagents): Hexanesulfonate, Octanesulfonate, Dodecanesulfonate salts, typically used for basic analytes.
• Alkyl Ammonium Salts (Cationic Reagents): Tetrabutylammonium (TBA), Tetraethylammonium (TEA), Hexylammonium salts, typically used for acidic analytes.
• Volatile Reagents: Specifically designed for LC-MS applications (e.g., TBA-TFA, Hexylammonium Formate).
• Solid & Liquid Concentrates: Offered in convenient forms for precise preparation of mobile phases.

Technical Considerations

• Concentration Optimization: The concentration of the ion pair reagent in the mobile phase is critical for achieving optimal separation.
• Mobile Phase pH: Adjusting pH can significantly influence ion pair formation and retention.
• Column Equilibration: Ensure sufficient equilibration time for the ion pair reagent to interact with the stationary phase.
• MS Compatibility: Always select MS-compatible reagents if coupling with mass spectrometry to avoid ion suppression or source contamination.
• System Cleaning: Regular flushing of the LC system is recommended, especially when switching between different ion pair reagents or non-volatile vs. volatile additives.

Why Choose Us?

We are committed to providing chromatographers with the highest quality consumables and reagents. Our Ion Pair Reagents are backed by:

• Rigorous Quality Control: Each batch undergoes extensive testing to ensure purity, consistency, and performance.
• Expert Technical Support: Our team of experienced chemists is available to assist you with method development, troubleshooting, and product selection.
• Comprehensive Product Range: A wide selection to meet all your ion pair chromatography needs.

Unlock the full potential of your challenging separations. Browse our comprehensive catalog of Ion Pair Reagents and find the perfect solution for your analytical workflow today!

For Research and Analytical Use Only. Not for human or animal therapeutic or diagnostic use.